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Microglia in IS usually present an M1 phenotype, a state in which they have a destructive effect on neurons and are detrimental to the recovery of brain tissue functions (38)

Nat Commun 11(1):1290 Jeon SM, Chandel NS, Hay N (2012) AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

Jain A, Pooladanda V, Bulbake U, Doppalapudi S, Rafeeqi TA, Godugu C, et al

the GHK-Cu complex operates through dozens of mechanisms simultaneously collagen synthesis, ECM organization, MMP suppression, antioxidant defense, and gene expression modulation across ~4,000 targets

Topoisomerase I is a target of SN-38, the active form of CPT-11