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10.1016/S2468-2667(19)30248-8 122 KivimkiM.VahteraJ.TabkA

In a frequently cited study, GHK-Cu introduced by repeated injection into stainless-steel wire-mesh wound chambers implanted subcutaneously in rats produced a concentration-dependent increase in the accumulation of connective tissue, raising dry weight, DNA, total protein, collagen, and glycosaminoglycan content at the repair site, while an inactive control tripeptide did not

Future research should explore the specific roles of gut microbes, long-term effects on the gut-brain axis, and vagus nerve involvement, with a focus on personalized probiotic interventions