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Moreover, we highlight recent therapeutic advances including the Food and Drug Administration (FDA) approval of resmetirom in 2024 and other promising agents currently in phase 2/3 trials providing a timely and translationally relevant overview that bridges current scientific evidence with emerging clinical applications in MASLD

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Notably, 13 C-glucose tracing revealed delayed labeling of the intracellular pool of fully labeled glucose and tricarboxylic acid cycle metabolites, together with enhanced labeling of pentose phosphate pathway intermediates and glutathione in iNs, indicating a shift toward biosynthetic and antioxidant glucose utilization during differentiation

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