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Western blotting revealed that upregulation of Ndufa1 dramatically attenuated Hcy-induced synapse-associated protein reduction, including N-methyl-D-aspartic acid receptor type 2 A (GluN2A), N-methyl-D-aspartic acid receptor type 2B (GluN2B), glutamate receptor ionotropic (GluN1), postsynaptic density protein 95 (PSD95), and Synapsin 1 (SYN1) (Fig