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Cytochrome p450 CYP2C9 is likely to be a major CYP isoform catalyzing fluoxetine N-demethylation in human liver microsomes at a substrate concentration close to the therapeutic level, while polymorphic CYP2C19 may play a more important role in this metabolic pathway at high substrate concentration

Both prostacyclin and NO are endothelium-derived vasodilators that mainly play a role in vasodilation of the large arteries, while EDHF plays a role in the vasodilation of arteries less than 500 m in diameter, especially those less than 100 m in diameter (Rath et al., 2009)