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H 2 S and pyruvate production with fluorescent probe detection Kinetic H 2 S production was measured using AzMC (Sigma #802409), which is a fluorogenic probe selectively reduced in the presence of H 2 S producing 7-amino-4-methylcoumarin 29 and detectable with excitation wavelength Exc 350 nm and emission wavelength Emi 445 nm

Recent studies demonstrated that KD improved motor function and protected dopaminergic neurons in MPTP-induced mouse model of PD [68]

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This results in the inhibition or reduction of the synthesis of the target protein

In cancer, aberrant activation of the ERK1/2 pathway often results in enhanced cell proliferation and resistance to apoptosis (Zhang et al., 2020[149]