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DCM is a specific form of cardiomyopathy caused by diabetes, characterized by cardiomyocyte hypertrophy, fibrosis, cardiac dysfunction, and arrhythmias ( through deubiquitination, which in turn promotes the transcription of mitofusin 2, thus protecting mitochondrial morphology and function and alleviating diabetic HF

Progesterone exerts antidepressant-like effect in a mouse model of maternal separation stress through mitigation of neuroinflammatory response and oxidative stress

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In addition, Shulman and colleagues reported that a HFD induced an increase in acetate production in the intestine of mice, and then the increased acetate level led to activation of the parasympathetic nervous system and promoted secretion of growth hormone-releasing peptide and glucose-stimulated insulin