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The term allergy was first used in 1906 by Clemens von Pirquet to describe patients who were hyperresponsive or hypersensitive to exogenous substances ( atopos means out of place) are caused by type I hypersensitivity reactions

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WilsonDEvansMGuthrieNSharmaPBaisleyJSchonlauFet alA randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of Pycnogenol for improving allergic rhinitis symptoms