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In the cytoplasm, a destruction complex comprising adenomatous polyposis coli (APC), AXIN, casein kinase 1 (CK1) and glycogen synthase kinase 3 protein (GSK3 protein) captures -catenin by phosphorylating CK1 and GSK3, thus activating the process of -catenin degradation

For example, islet-specific miR-375 overexpression represses glucose-stimulated insulin secretion (GSIS) and insulin gene transcription, that is then reversed upon miR-375 inhibition

In this short review paper, we have selected the ROS, briefly summarized their main characteristics, described their prooxidant activities, and outlined the most prominent antioxidants in plants

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However, it is necessary to directly study muscle cells, since there are key differences in the signalling and trafficking machinery between adipocytes and myocytes, for example in the major Rab proteins responsible for insulin-regulated GLUT4 delivery to the cell surface (Rab8a and 13 in muscle [118]