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The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months

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Absence of early results in a supervised clinical setting is information that leads to protocol adjustment, not continuation without review

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CdsA: phosphatidate cytidylyltransferase

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This is particularly true when copper peptides are combined with exfoliating acids or retinoids , which can compromise the skin barrier

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