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8 Conclusion Chronic stress may contribute to cognitive dysfunction in ME/CFS by disrupting HPA-axis homeostasis and adversely affecting key cognitive regions such as the hippocampus

Myeloid compartment Monocytes/Macrophages and ASCVD Classical monocyte-derived macrophages are important in the early steps of atherogenesis as they contribute significantly to the creation of an inflammatory microenvironment

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Another study highlighted that synbiotics may modulate the neuroinflammatory markers such as TNF- and IL-6 that are found to be elevated in the case of PD (119)

doi: 10.3389/fnins.2021.587197 Received 25 July 2020 Accepted 10 February 2021 Published 16 March 2021 Volume 15 - 2021 Edited by Anwen Shao, Zhejiang University, China Reviewed by Yi Yang, First Affiliated Hospital of Jilin University, China