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Glutathione reductase (GR), which reduces oxidized glutathione to glutathione (GSH), plays a crucial role in the glutathione redox cycle and has become a subject of intense global research

Myeloid PHGDH deficiency reverses diet-induced obesity Inflammatory macrophage activation plays a decisive role in adipose tissue inflammation ( 35 , 36 ), and targeting mitochondria in macrophages holds promise for therapeutic treatment of obesity-related disorders ( 37 )

Structural mechanism for rifampicin inhibition of bacterial RNA polymerase

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This exacerbates immune dysregulation by affecting macrophage polarization and the balance of T cell subsets, thereby participating in the pathological process of PH (Cao et al., 2024)