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Due to the interconnection of glycolysis and Oxphos, there is dynamic interchange between cytoplasmic and mitochondrial NAD + , as depletion of cytoplasmic NMNAT2 also depletes mitochondrial NAD + 77

Compared to the liver, we observed that the kidney has: (1) similar increased use of energy-related metabolites and production of urea cycle and ammonia-related intermediates, suggesting a shared catabolism in AKI, and (2) higher pools of energy metabolism intermediates in AKI

2g and Extended Data Figs

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Body measurements including waist, hips, thighs, and arms at consistent points provide direct feedback on composition changes