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Therapeutic strategies targeting MDSCs Metabolic targeting in MDSCs MDSCs display high metabolic reliance and undergo extensive metabolic reprogramming in the TME to adapt to harsh conditions, such as hypoxia, oxidative stress, and nutrient scarcity (6)

Metabolites 11 , 55 (2021)

For example, the Se-containing polysaccharide SeGLP-2B-1 disrupts the mitochondrial membrane potential and enhances the cytosolic Cyt-c levels and the activity of caspases 9 and 3 [300,301]

Lipid peroxidation, a consequence of oxidative stress induced by radiation, entails the degradation of lipids when reactive oxygen species (ROS) generated by radiation interact with polyunsaturated fatty acids in the phospholipid membrane bilayer [49]