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Description

Since the nocturnal concentration of melatonin is approximately 310 times higher than the daily one (Odaci and Kaplan, 2009), the nocturnal application of the exogenous melatonin would be reinforced by the physiological peak of melatonin at night, thus leading to enhanced effects on regeneration according to Rateb et al

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[DOI] [PMC free article] [PubMed] [Google Scholar] 184

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Similar content being viewed by others 1 Background Inflammatory bowel disease (IBD), mainly Crohn's disease (CD) and ulcerative colitis (UC), is a significant etiology of chronic gastrointestinal (GI) disease all over the world, with various manifestations and multifactorial nature

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