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Reports of improved metabolic parameters hyperglycemia, insulin resistance, blood pressure, weight, and liver disease as well as motor, pain, and urinary frequency were reported in studies achieving therapeutic ketosis. There are at least a few proposed mechanisms related directly to ketone body signaling (Fig

doi: 10.1111/jcpe.12711 58 NitureSKJaiswalAK

(2021) reported that m6A modification appeared to enhance Beclin-1-mediated autophagy and consequently trigger ferroptosis in human HSCs, which is further confirmed by silencing YT521-B homology domain family, a critical m6A reader protein for sustaining Beclin-1 mRNA stability

We exposed 3D cardiac and hepatic microtissues to medium with or without 0.1% DMSO and analyzed the transcriptome, proteome and DNA methylation profiles

[DOI] [PubMed] [Google Scholar] 41.Forman H.J., Zhang H., Rinna A