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We consider whether current disease-modifying therapies for relapsingremitting MS meet the criteria for successful therapeutics in PMS and suggest that the evidence favours the early introduction of sphingosine 1-phosphate receptor modulators

Generally speaking, bracket prescriptions vary significantly from one patient to the nextand even from the right to left side of the same patient

Periodontal disease is associated with renal insufficiency in the atherosclerosis risk in communities (ARIC) study

Spending time outdoors in natural light, particularly in the morning hours, improves sleep onset and quality that night

Therapeutic translation bottlenecks are prominent: compounds effective in preclinical studies (e.g., andrographolide) often fail in human trials, as animal models cannot replicate patients individual differences and complex pathology (124)