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Once B12 has been released from dietary proteins, it binds to salivary haptocorrina, a binding protein (also called protein R or cobalofilin) secreted in the salivary glands and binds in the stomach with cobalamin, which has a high affinity for this protein, forming a complex with it as it passes into the duodenum

In the present study, 18 subjects were assigned to each of the considered two groups to detect a change of 4.7 mol/l in serum levels of homocysteine with 90% power and 5% significance

With the exception of this, a tumorigenic effect has only been shown in the past in an animal experiment with rats (EFSA, 2006)

A tolerable upper intake level (UL)the amount you can safely take without risk of severe side effectswas never set for it because it has a low potential for toxicity, and the body does not store it in excess (NIH-a, 2021)

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