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331 However, intranasal NOD2 ligand induces the expression of TSLP, IL-25 and OX40L in the lung, 332 and these three molecules have been reported to promote asthma-related inflammation, 333,334,335 blunt the production of antigen-specific CD4 + Foxp3 + adaptive Tregs, and simultaneously drive CD4 T cells to produce IL-4, change the Treg/Th2 balance, block tolerance, and promote the susceptibility of airway inflammation dominated by eosinophils

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