Proteomics data are available via ProteomeXchange with the identifier PXD042314 ( Abbreviations ASD: autism spectrum disorders CNS: central nervous system CGI: Clinical Global Impression DEGs: differentially expressed genes DEPs: differentially expressed proteins EV: extracellular vesicles FC: fold change GCP: Good Clinical Practice GO-BP: Gene Ontology-Biological Process GSEA: Gene Set Enrichment Analysis IRB: Institutional Review Board LR: ligandreceptor LCMS/MS: liquid chromatography tandem mass spectrometry MCID: minimal clinically important difference NK: natural killer NTA: nanoparticle tracking analysis PBMCs: peripheral blood mononuclear cells PBS: phosphate-buffered saline PD: Proteome Discoverer pDCs: Plasmacytoid dendritic cells PHGDH: Phosphoglycerate dehydrogenase SEM: standard error of the mean TADA: Transmission and de novo Association WGCNA: Weighted gene co-expression network analysis References Maenner, M
Anti-inflammatory Action: It's been observed to modulate inflammation, a key factor in both acute injury and chronic conditions
Am J Med Genet 44:5256 Brooker G, Jeffery J, Nataraj T, Sair M, Ayling R (2007) High anion gap metabolic acidosis secondary to pyroglutamic aciduria (5-oxoprolinuria): association with prescription drugs and malnutrition
First, phase II clinical trials evaluating MOTS-c in type 2 diabetes and sarcopenia are in development, and their results will provide the first randomized controlled evidence in humans to define therapeutic doses with statistical rigor
4 Common compounds/drugs inhibiting ferroptosis in central nervous system diseases The studies on ferroptosis in central nervous system disorders have preliminarily demonstrated that ferroptosis inhibition holds significant potential in conditions such as IS, PD, AD, and TBI
