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While the protective effect of folate against NTD is well established, only a few studies have investigated the role of other methyl group donors, including choline and betaine, in the occurrence of NTDs

Matthews JS, Adams JB

Matsui H, Einama T, Shichi S, et al

Pharmacology [edit] Pharmacodynamics [edit] Although the mechanism of action of valproate is not fully understood, [38] traditionally, its anticonvulsant effect has been attributed to the blockade of voltage-gated sodium channels and increased brain levels of the inhibitory synaptic neurotransmitter gamma-aminobutyric acid (GABA)