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Myoblast Proliferation and Anti-Differentiation Yang and Goldspink (2002) in FEBS Letters the foundational paper for synthetic MGF E-peptide research confirmed that MGF E-domain peptide increases myoblast proliferation while inhibiting terminal differentiation of C2C12 cells, in contrast to mature IGF-1 which primarily promotes differentiation with a lesser proliferative effect

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Yang, Y., Xu, J., Zhou, J., Xue, J., Gao, J., Li, X., Sun, B., Yang, B., Liu, Z., Zhao, Z., Luo, Q., Zeng, Q., Zheng, L., & Xiong, C

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