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10.1161/JAHA.116.004328 86 LiuM.HeA.ChuJ.ChenC.ZhangS.HeY.et al (2018b)

Klauser P, Xin L, Fournier M, Griffa A, Cleusix M, Jenni R, et al

As metabolism becomes dysregulated, fat cells in the liver secrete excess eNAMPT, promoting a vicious spiral of illness

Here, we review the mechanism of action of cisplatin, the mechanism of resistance to cisplatin, the role of metabolic remodelling in tumorigenesis and development, and the effects of common metabolic pathways on cisplatin resistance