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Both in vitro and in vivo studies have shown that inflammatory factors such as IL-1 and TNF- upregulate the expression of ASIC1a, which promotes chondrocyte apoptosis, as demonstrated in both a rat adjuvant arthritis model and a primary articular chondrocyte model

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Dev Comp Immunol 52:215225 Cooray R, Petersson CG, Holmberg O (1993) Isolation and purification of bovine myeloperoxidase from neutrophil granules

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doi: 10.1007/s00253-009-1893-z 411 TianL.HiresS