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Common reactions include: Local injection site pain or erythema Headache or dizziness Transient flushing Rare: Anaphylaxis or hypersensitivity Causes and Consequences of Impaired Methionine Synthase Activity in Acquired and Inherited Disorders of Vitamin B Metabolism

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By inhibiting NNMT, 5-Amino-1MQ reduces 1-MNA formation and alleviates the methyl sink, increasing SAM availability for other methylation reactions, while freeing nicotinamide for recycling through NAMPT toward NAD