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In a pilot study of 32 migraine sufferers with insulin resistance, supplementation with 400 mg lipoic acid twice daily for six months significantly reduced the number of migraine attacks and days needing treatment, with improvements seen as early as two months (Cavestro 2018)

& Andrews, S

Similarly, other experiments replicated the positive effects of SIRT1 activation including enhanced mitochondrial biogenesis by inducing eNOS expression (229)

Biochem J 473(7):805825 Davin LB, Lewis NG (2000) Dirigent proteins and dirigent sites explain the mystery of specificity of radical precursor coupling in lignan and lignin biosynthesis