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22 This has the potential to lower stroke risk because nitric oxide is a signaling molecule that endothelial cells use to communicate information about blood flow and pressure to muscles in the artery walls, telling them to constrict or relax appropriately in response and distributing blood flow appropriately

Neutrophils are the most abundant leukocytes in the system and play a major role in the innate immune response

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This was demonstrated in an in vivo model of acute LPS/IFN--induced neuroinflammation, where STAT3 and ERK signaling induced IL-6 production, which protected against neuronal apoptosis (133)