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[PMC free article: PMC4824140] [PubMed: 26814015] 78

IJC Heart and Vasc

Because it works at a cellular level to reduce oxidative stress, the most significant benefits are often cumulative and develop over several months of a steady routine

Why does this trend dominate

Tranexamic acid (TXA), a lysine analogue and antifibrinolytic agent, inhibits the binding of plasminogen originating from endothelial cells to keratinocytes resulting in the diminution of melanocyte activators production (e.g., arachidonic acid, prostaglandins, leukotrienes, -MSH) [6, 27, 90]