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They emerged in 2007 thanks to the research of Yamanaka and Takahashi, who discovered the four transcription factors (Oct4, Sox2, Klf4, and c-Myc, abbreviated as OSKM) necessary for human fibroblasts reprogramming (Takahashi et al., 2007)

BHRF1 prevents type I IFN pathway activation by encouraging mitochondrial fragmentation, which ultimately contributes to autophagosomes degradation by mitophagy

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Amandine Grimm, University of Basel, Switzerland Updates Copyright 2019 Braidy, Zarka, Jugder, Welch, Jayasena, Chan, Sachdev and Bridge

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