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The nuclear factor-kappa B (NF-B) transcription factor has been identified as the key factor during inflammation which can be stimulated by oxidative stimuli

PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons

Higher incidence of autoantibodies in X-linked chronic granulomatous disease carriers: random X-chromosome inactivation may be related to autoimmunity

419,420,421,422 Cyclin D1 restrains glucose uptake and glycogen synthesis via HNF4-regulated metabolic adaptation

However, researchers had been unable to identify the precise mechanisms at play