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Robbins PW, Lipmann F (1958) Enzymatic synthesis of adenosine-5-phosphosulfate

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In the endoplasmic reticulum, POR and cytochrome b5 reductase 1 (CYB5R1) catalyze the electron transfer chain of NADPH/NADH, transferring electrons to oxygen molecules to generate HO, which reacts with iron ions via the Fenton reaction to produce hydroxyl radicals that attack PUFAs in the cell membrane, initiating lipid peroxidation and ultimately inducing ferroptosis[36]