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Science 380 , eabn9257 (2023)

How Much Creatine Should You Take: The recommended daily dosage of creatine varies, but a common approach is to start with a loading phase of 20 grams per day (split into 4-5 doses) for 5-7 days, followed by a maintenance phase of 3-5 grams per day

Primers used were as follows: Gpx4 (forward: 5-AGT ACA GGG GTT TCG TGT GC-3

This review will focus on recent findings describing how different pathological states compromise BBB integrity, discuss current potential therapeutic approaches that have been explored for improving BBB integrity and slowing neurodegenerative disease pathologies, and the recent findings in microbial mediated modulation of the BBB

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