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Glycocalyx function Regulating vascular permeability Notably, glycocalyx degradation exacerbates vascular permeability by disrupting VE-cadherin and occludin [41], while intact glycocalyx suppresses MMP-9-mediated inflammation [42, 43]

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10.1111/jsr.14073 [DOI] [PubMed] [Google Scholar] 161.Afaghi A, OConnor H, Chow CM

This indicates that PRNP may function as an important gene modifier in WD 21 , and the Cu-binding and transporting properties of WD-modulating variants of PrP warrant further investigation