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Two of these patients were treated more than three months before the data were released in December 2014

Injecting directly into muscle is usually more painful than injecting into the subcutaneous layer of fat below the skin

Sinclair et al., 2021), partially because that NPs have higher electrostatic interactions to negatively charged cellular membranes, thus increasing cellular uptake of NPs, leading to more cell damages (Frohlich, 2012