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A 2014 review (PMID 25098945) reported positive copper patch-test reactions in a weighted average of about 3.8% of tested subjects, and earlier work on the dermatologic aspects of copper hypersensitivity (PMID 15327478) similarly described it as infrequent but real in selected cases

3 The active molecule turned out to be a tripeptide with the sequence glycine-histidine-lysine (Gly-His-Lys), which has a strong natural affinity for copper(II) ions

These molecules modulate gene expression at transcriptional and post-transcriptional levels, influencing inflammation, oxidative stress, and neuronal repair

If your provider is unfamiliar with these tests, you can bring printed copies of peer-reviewed studiessuch as the Brewer or Wu studies on mycotoxins in ME/CFSto help guide the conversation

The proven contribution of visible light in skin hyperpigmentation and dyschromia has led to the addition of pigments (iron oxides) in formulations to protect against VL [41]