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OXPHOS), copper homeostasis (e.g., ATP7B/CTR1 expression), genetic landscape (e.g., ARID1A , SF3B1 , TP53 status), and TME context (e.g., HIF-1 activity, immune cell infiltration)

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In plants, GLR activation triggers Ca 2+ influx, which in turn stimulates NO accumulation through Ca 2+ /calmodulin-dependent pathways analogous to those in animal cells (Bonfoco et al