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Huang and Pranata, 2020

Microbes Infect.Feb 2013;15(2):152-156

Disturbances in iron metabolism are typical of subarachnoid hemorrhage (ASH), and in the treatment of ASH with oncostatin M (OSM, an iron-regulator inducer) it was found that the expression of hepcidin was increased and the expression level of Fpn1 was decreased by the action of OSM, enhancing the sensitivity to ferroptosis [35]

Furthermore, our previous omics analysis of fibroblasts isolated from a MSS patient identified an upregulation of CAT and both the isoforms of SOD (Cu-ZnSOD, MnSOD) 26,30

A post-hoc subgroup analysis of that trial suggested benefit of prasinezumab in subjects with faster progression [209] and a comparison of MDS-UPDRS progression during the 4-year open-label extension phase with historical controls showed divergent trajectories in favour of prasinezumab from year 2 of treatment onwards [210]