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Inhibiting glutamine pathway, including downregulating glutamine transporter ASCT2 [84] or inhibit glutaminase by CB-839 [85] can deplete intracellular GSH, but such effect of CB-839 was only observed in cancer cell lines expressing xCT supplied with high cystine in the culture [86]

Panchamoorthy G, Jin C, Raina D, Bharti A, Yamamoto M, Adeebge D, Zhao Q, Bronson R, Jiang S, Li L

After ferroptosis was inhibited by ferrostatin-1 treatment in C57BLKs/J mice, urinary albumin to creatinine ratio was decreased, kidney tubular injury and kidney fibrosis were improved, HIF-1 and HO-1 expression were suppressed [78]

Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling

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