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Kaneto H, Obata A, Kimura T, Shimoda M, Kinoshita T, Matsuoka T-A, et al

(Outlines contraindications for niacin therapy, including active peptic ulcer disease, active liver disease with elevated enzymes, hypersensitivity to niacin, and arterial bleeding, as well as monitoring recommendations for blood pressure, glucose, uric acid, etc., due to niacins systemic effects)

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If your skin is reactive or easily irritated, once daily may be enough