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This can be regarded to the deleterious effect of ROS on macromolecules and their role in activating inflammatory transcriptional factors and hence their damaging effect on pancreatic tissue ( The L-arginine-induced model of AP represents one of the most commonly utilized animal models to investigate the pathological changes in the pancreas due to its similarity to the human phenotype of the disease ( Arginine specifically targets acinar cells in the pancreas without affecting other cellular components of the pancreas ( Dipeptidyl peptidase-4 (DPP-4) is a glycoprotein enzyme found on cell membranes of natural killer (NK) cells, macrophages, B-cells and T-cells among others

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In addition to the basic genotypes outlined below, certain specialized strains are available to confer greater transcriptional control, assist with proper protein folding, and deal with sub-optimal codon usage (Table 1) A few mutations are common to all or most expression strains to accommodate high protein levels including: ompT: Strains harboring this mutation are deficient in outer membrane protease VII, which reduces proteolysis of the expressed recombinant proteins