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Flavonoids can be summarized to reverse MDR via multiple mechanisms such as regulating the ABC transporters, boosting ROS production in cancer cells, or conversely inhibiting the activities of the anti-oxidative enzymes, subduing the proliferation of cancer stem cells, inhibiting EMT (epithelialmesenchymal transition) signalling, modulating autophagy and the related factors, and lastly, by distorting the progression of cell cycle in cancer cells [202]

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Free heme is dangerous in excessive quantities (15) which is why it is quickly removed from tissues through hydrolyzation by microsomal heme-oxygenase, specifically at the -methane bridge

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