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Glutamate-modulating drugs are, therefore, becoming more and more popular for treating OCD and OCRD

Pharmacological inhibition of GLS via CB-839 or BPTES amplifies PCa cell sensitivity to metformin ( 4.3.7 Limitations of drugs targeting ammonium metabolism Although systematic investigations into the adverse effects of ammonium metabolism-targeting agents in prostate cancer remain limited, their toxicological profiles have been relatively well characterized in other solid tumors, such as breast, pancreatic, and gastrointestinal cancers (211, 222, 238)

Additionally, the gut microbiota generates small molecule metabolites like indole and its derivatives, which possess anti-inflammatory and antioxidant properties and can protect the BBB from damage (Feng et al., 2023)

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Without early administration of the antidote, fulminant liver failure follows, often in combination with kidney failure, and death generally occurs within several days