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It is rapidly cleared by renal filtration and degraded by proteases before sustaining meaningful receptor engagement in preclinical in vivo systems

Unfortunately, this trial did not pass Phase I with five of the seven enrolled patients experiencing serious adverse effects, including supraventricular tachycardia, convulsion, and pulmonary embolism

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Having this new option provides physicians with a tool that will help prevent the life-changing amputation of ones frostbitten fingers or toes, said Norman Stockbridge, director of the Division of Cardiology and Nephrology at the FDAs Center for Drugs and Evaluation Research, in a statement