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Both peptides show systemic bioactivity but act most strongly at sites of injury or inflammation

Autophagy promotes ferroptosis by degradation of FTH in fibroblasts and cancer cells, demonstrating the co-existence and mutual regulation of autophagy and ferroptosis in stromal and tumor cells (61)

TABLE 1 Reagents that modulate ferroptosis in animal models or patients of CNS diseases

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In multiple sclerosis (MS), reactive astrocytes similarly surround the lesions, form borders and support the formation of fibrotic scar, although astrocytes present asthenia and loss of homeostatic functions 187,188