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MOTS-c binds cellular targets to trigger AMPK phosphorylation, enhancing glucose uptake and lipid oxidation in cell assays

Whilst fatty liver disease itself may not directly cause B12 deficiency, the constellation of metabolic conditions, medications, and lifestyle factors commonly associated with fatty liver can collectively increase vulnerability to deficiency

doi:10.1016/j.ccc.2012.07.003

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These scientists concluded as follows: Although there are many opinions about the risks or benefits of antioxidant supplementation, the only supportable conclusions based on the present research are that there is no evidence of antioxidant supplementation causing harm alongside cancer therapy, except for smokers undergoing radiotherapy. The caveat for smokers is based on a trial in head and neck cancer patients in which supplementing with alpha-tocopherol and beta-carotene during radiotherapy had a negative impact on rates of cancer recurrence and death in participants who smoked during the trial (Meyer 2008)