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Mutations in genes such as PNPLA3 or adiponutrin (involved in remodeling of hepatic fatty acids), 29 transmembrane 6 superfamily member 2 (TM6SF2) (involved in lipidation of VLDL in a pre-Golgi compartment of liver), 30 membrane-bound O-acyl transferase domain-containing protein 7 (involved in phospholipid remodeling), 31 and glucokinase regulatory protein (regulator of hepatic DNL) 32 increase the risk of developing MAFLD

The NRF2-sMAF complex binds to the antioxidant response element (ARE, also referred to as CsMBE) within the promoters of its target genes

The biochemical pathways of single PUFA oxidation can result in the formation of over 100 different volatile and semivolatile compounds, which can be classified into alkanes, alkenes, aldehydes and their derivatives, carboxylic acids, esters, furans and epoxides, as presented in a mechanistic study of Ratcliffe et al

It is an essential amino acid that is taken in from their feed