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The anorexia associated with cancer cachexia is likely caused by the activity of pro-inflammatory cytokines, such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), interleukin-6 (IL-6) and growth differentiation factor 15, that are produced either by the tumor or by the host in response to the tumor, which interfere with appetite signals within the anterior hypothalamus ( Undernutrition is a common problem in patients with cancer cachexia and can be a consequence of both reduced dietary intake, poor dietary quality and hypermetabolism ( For a long time, undernutrition and cachexia remained neglected medical conditions for which a clear therapeutic strategy was lacking

Lenvatinib inhibited cell proliferation and apoptosis in an organoid model with low YAP/TAZ expression, and co-administration of atorvastatin restored the inhibitory effect of lenvatinib on cell proliferation and apoptosis by suppressing YAP/TAZ expression in an organoid model with high YAP/TAZ expression

The reaction mixture was prepared using the standard protocol for FastStart Essential DNA Green Master (Roche Diagnostics)