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When the cellular iron content is high, iron-bound NCOA4 interacts with the ubiquitin E3 ligase HERC2 to target NCOA4 for proteasomal degradation, which subsequently reduces ferritinophagy

PPAR-gamma agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis

Acta Pharm Sin B 10:582602

83 Leflunomide Leflunomide reduces inflammation in the joints of RA patients by inhibiting dihydroorotate enzymes essential for producing DNA and RNA, particularly in activated proliferation lymphocytes