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Methods: We developed a biomimetic autophagy degradation peptide (MNP-PDL1) using the lysosomal autophagy system in conjunction with biomimetic membrane technology, which consists of a PD-L1-binding sequence, a PEG3 linker, and a target lysosomal chaperone protein recognition sequence (CIP), which can localize the target protein, PD-L1, to the lysosome for degradation

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