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NADPH oxidase- generated O 2 , besides NO scavenging, triggers eNOS uncoupling (the mechanisms are discussed in the next section), and uncoupled eNOS becomes itself a source of superoxide [19]

Biomaterials 308, 122544

4.3 Theoretical mechanism for the selenenylsulfide to attack the S-S bond of DTNB or the S-N bond of GSNO Our observations can be rationalized by understanding the type of bonds that participate in reactions with selenenylsulfide bond (S-Se bond), which becomes highly polarized (R2 in Figure 3) under our experimental conditions at pH 7.5